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Research Direction 1: Investigating the Molecular Mechanisms of Novel Oncogenes in Cancer
Research Direction 1: Investigating the Molecular Mechanisms of Novel Oncogenes in Cancer
This research primarily focuses on the oncogenic basic helix-loop-helix (bHLH) transcription factor SPZ1 (Fig. 1) and the homeobox gene ISX (Fig. 2). We investigate how these factors induce and participate in the remodeling of the tumor microenvironment, thereby driving tumor cell proliferation, metastasis, progression, and immune evasion. By identifying and characterizing the regulatory networks of these genes, this study aims to elucidate the fundamental mechanisms underlying carcinogenesis, disease progression, and malignancy.
Research Direction 2: Impact of Dendritic Cell and Macrophage Development on Disease and Immunocompetence
Research Direction 2: Impact of Dendritic Cell and Macrophage Development on Disease and Immunocompetence
At the immunological level, we utilize bone marrow cells from various knockout (KO) mouse models for in vitro cultivation to induce differentiation into dendritic cells (DCs) or macrophages. Through co-culture assays with cancer cells, we investigate how specific genetic regulation within these immune cells influences tumor cell behavior.
In addition to in vitro experiments, we perform in vivo challenges by injecting cancer cells into these knockout mice. We employ the In Vivo Imaging System (IVIS) to monitor real-time tumor growth and progression, thereby elucidating the systemic impact of specific immune cell gene deletions on the tumor landscape. At the molecular level, our research focuses on how the expression of these genes modulates mitochondrial dynamics and endoplasmic reticulum (ER) function.
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